Encodes a protein that binds to beta-sitosterol and localizes to the ER. The WFDE motif in ORP3a appears to be important for a direct interaction with PVA12 [Plant VAMP-Associated protein 12]. Mutation of this motif causes ORP3a to relocalize to the Golgi and cytosol. The interaction between PVA12 and ORP3a does not appear to be sterol-dependent.
Computational Description
UNFERTILIZED EMBRYO SAC 18 (UNE18); CONTAINS InterPro DOMAIN/s: Oxysterol-binding protein, conserved site (InterPro:IPR018494), Oxysterol-binding protein (InterPro:IPR000648); BEST Arabidopsis thaliana protein match is: OSBP(oxysterol binding protein)-related protein 3B (TAIR:AT3G09300.1); Has 2336 Blast hits to 2302 proteins in 216 species: Archae - 0; Bacteria - 0; Metazoa - 1125; Fungi - 658; Plants - 280; Viruses - 0; Other Eukaryotes - 273 (source: NCBI BLink).